Protease Inhibitors and Phosphatase Inhibitors
MilliporeSigma™ Calbiochem™ Arp2/3 Complex Inhibitor I, CK-666
The Arp2/3 Complex Inhibitor I, CK-666, also referenced under CAS 442633-00-3, controls the biological activity of Arp2/3. This small molecule/inhibitor is primarily used for Cell Structure applications.
MilliporeSigma™ Calbiochem™ Spautin-1
A quinazolin compound that acts as a specific and potent inhibitor of autophagy and promotes Vps34 PI 3-kinase complex degradation by blocking the activity of USP 10 (IC50 = 580nM) and USP 13 (IC50 = 690nM) deubiquitinating enzymes
MilliporeSigma™ Calbiochem™ Glycogen Phosphorylase Inhibitor II, KB228
A mixed type inhibitor of muscle glycogen phosphorylase (Ki = 930 nM).
MilliporeSigma™ Calbiochem™ USP1-UAF1 Inhibitor, ML323
A cell-permeable, selective, potent, and reversible inhibitor of USP1-UAF1 deubiquitinase (IC50 = 76 nM in Ub-Rhodamine based assays). Does not disrupt USP1-UAF1 association.
MilliporeSigma™ Calbiochem™ Rolipram
A cell-permeable, selective inhibitor of cAMP-specific phosphodiesterase (PDE IV; IC50 = 800 nM).
MilliporeSigma™ Calbiochem™ Leupeptin, Hemisulfate, Microbial
Leupeptin hemisulfate, CAS 103476-89-7, is a reversible inhibitor of trypsin-like proteases and cysteine proteases.
MilliporeSigma™ Calbiochem™ Stearoyl-CoA Desaturase 1 Inhibitor, MF-438
Stearoyl-CoA Desaturase 1 Inhibitor, MF-438, CAS 921605-87-0, is a cell-permeable inhibitor of Stearoyl-CoA Desaturase 1 (SCD1; IC50 of 2.3nM).
MilliporeSigma™ Calbiochem™ Caspase Modulator I, 1541
A cell-permeable phenylimidazopyridinyl-methoxy coumarin compound that inhibits caspase-3 and caspase-6 activities (IC50 = 35 and 38μM, respectively) by targeting both the large and small subunit active si
MilliporeSigma™ Calbiochem™ JAK2 Inhibitor IV
The JAK2 Inhibitor IV, also referenced under CAS 1110502-30-1, controls the biological activity of JAK2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ TNF-α Antagonist
The TNF-α Antagonist controls the biological activity of TNF-α.
MilliporeSigma™ Calbiochem™ o-Phenanthroline
A metal chelating agent that prevents the induction of chromosomal aberrations in streptozotocin-treated cells.
MilliporeSigma™ Calbiochem™ Clioquinol
A metal ion chelator that crosses the blood brain barrier and acts as a neurotoxic antibiotic.
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MilliporeSigma™ Calbiochem™ α1-Antitrypsin, Human Plasma
α1-Antitrypsin, CAS 9041-92-3, is a protease inhibitor of the serpin superfamily. Inhibits elastase, cathepsin G, and proteinase 3.
MilliporeSigma™ Calbiochem™ Nα-Tosyl-Lys Chloromethyl Ketone, Hydrochloride
Inhibits trypsin-like serine proteinases.
MilliporeSigma™ Calbiochem™ RNA Polymerase I Inhibitor II, BMH-21
A cell-permeable compound that blocks the growth and viability of a variety of cancer cell lines (GI50 = 160 nM in NCI-60 cells), but does not affect normal cells.